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The rate of (Nitric
Oxide) NO production is critically dependent on the bioavailability
of Arginine. NO is a highly reactive, short-lived, lipophilic
molecule with a half life of a few seconds. L-Arginine Nitric
Oxide (NO) formulas are capable of producing excessive NO
or reduced endogenous NO production. Reduced arginine availability
results in reduced NO synthesis. Arginine availability for
NO synthesis is regulated by de novo arginine synthesis, arginase
activity, and cellular arginine transport. Arginase is generated
by excessive NO levels, and is to be avoided under any circumstance
in an L-Arginine or NO formula.
Excess
(excessive) NO creates a toxic environment in the human body,
and low levels of NO (reduced endogenous NO) are ineffective,
so NO highs and lows are to be avoided. In terms of fertility
in males, NO reduces or inhibits sperm motility, while NOS
inhibitors, which inhibit the formation of NO, prevent the
reduction of sperm motility, indicating a role for the L-arginine-NO
pathway in the modulation of sperm motility and motility survival.
Sperm
motility is negatively affective by both reduced and excessive
endogenous Nitric Oxide (NO). The mechanism of reduced fertility
in males, related to NO, is a function of the effect of reactive
oxygen species (ROS) on sperm membranes, which depresses sperm
function. Stress also exacerbates reduced motility of sperm.
Excessive NO levels in seminal plasma are associated with
poor sperm quality.
Excessive
generation of NO can be toxic and reduce sperm motility. Further,
excessive NO contributes to the formation of a highly toxic
anion of peroxidation, called peroxynitrite. The unpaired
electrons of NO and O2 define peroxynitrite as a 1-or-2-electron
oxidant and nitrating agent, and not a typical free radical.
Numerous
clinical studies have demonstrated that peroxidation decreases
sperm count and motility, and loss of the capacity of the
spermatozoon to undergo the acrosome reaction and fertilization.
Therefore,
NO formulas and products must be produced under strict GMP
manufacturing guidelines utilizing long-term proven methodologies
in L-arginine biochemistry.
The
manufacture of NO formulas and products should not be attempted
by persons unfamiliar with L-Arginine NO toxic byproducts
and the Blind Amino Acid personality of amino acids, such
as Arginine.
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